Mabqi

LiteMab©
Antibody Discovery Solution

Are you facing any of these bottlenecks in your antibody discovery workflow?​
  • Navigating the scientific / target complexity ? ​
  • Finding high-quality binders to develop ADC, bispecific, multispecific, TCE?​
  • How can I embed developability and functionality earlier to reduce downstream risk?​
  • How can I accelerate timelines without compromising candidate quality?​
  • How do we improve efficiency of antibody discovery and early development?

Supporting antibody discovery

At Mabqi, we have developed the LiteMab© Antibody Discovery studio to find the « perfect » antibodies that binds with high specificity to complex, low-expression targets, readily developable and functional.

LiteMab platform is specifically designed to tackle high-difficulty discoveries.

    • Fully human naive synthetic antibody library perfectly suited for any targets even hard to access, structurally difficult, especially multispanning membrane proteins and other “hard-to-drug” antigens.
    • Functionality-driven discovery workflow based on an advanced display platform
    • Selection on Recombinant protein, Peptides, cell lines + Small antigen quantity required
    • Full characterization & functional validation of the binders in 4 months

 

Our versatile platform excels in addressing complex programs by seamlessly integrating multiple requirements. This adaptability allows us to tackle a wide array of specifications, including:

  • Target specificity
  • Multi-species cross-reactivity
  • Agonist /antagonist properties
  • Enzyme inhibition capabilities
  • Conditionally active pH-sensitive antibodies with the LiteMab© Sense platform

For each target of interest, we perform customized antibody screening programs using our suite of synthetic human antibodies libraries and highly innovative, flexible and robust discovery workflows.

Our expert team provides comprehensive solutions for antibody discovery and development programs, delivering seamless support across the entire discovery workflow.

1. Optimal antibody selection strategies:

  • Ready-to-use fully human synthetic suite of libraries
  • Advanced screening workflow: AI-powered phage display and yeast display technologies
    Bio-panning strategies are performed on proteins, peptides, cells, liposomes, VLPs, …

2. Comprehensive antibody hits’ characterization

Comprehensive binding affinity evaluation for soluble and membrane-bound targets, EC50 binding potency assessment, cell-based flow cytometry assay to determine the binding potency based on cell line expression, epitope specificity, cross-reactivity, …

3. Rigorous functional validation processes: internalization assays, direct cytotoxicity assays, ….

Don’t let antibody discovery hold your pipeline back!

Looking for a partner?

If you’re working on challenging targets, advanced modalities and need a specialized discovery partner,  Let’s connect!

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