LiteMab© Neo
Affinity Maturation

Benefit of Mabqi’s expertise in library design, extensive know-how in affinity and pH-sentivity maturation workflows to push your drug candidates toward higher potency, cleaner safety profiles, and better odds of regulatory and commercial success.

Based on your parental clone, different options are available (can be also combined )​

• LiteMab© Neo for Affinity maturation :​
  
  • Increase binding strength ​
  • Sharpen specificity, reducing off‑target binding and improving both safety and therapeutic window.​
  • De‑risk development by reducing the chance of late‑stage failures due to weak potency or poor target engagement.
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• LiteMab© Neo Sense for pH‑sensitivity maturation :​
  
  • Optimize antigen binding in the tumor microenvironment environment (TME) while favoring weaker binding or even release in normal‑pH tissues to reduce on‑target off‑tissue toxicity.​
  • Improve pharmacokinetics and tissue penetration, for example by enabling “pH‑dependent” recycling or release in endosomal compartments.​
  • Enhance manufacturability and stability: understanding and controlling pH sensitivity helps formulation scientists design buffers that minimize degradation, aggregation, and loss of activity over shelf life.