Therapeutic human antibodies Discovery campaigns & maturation programs

Supporting your antibody drug discovery and maturation programs

Maximize the success of your antibody discovery and maturation projects by leveraging our LiteMab© Antibody Discovery Studio.

Mabqi is committed to delivering 100% human functional antibody leads for various therapeutic applications and areas such as oncology, neuroscience, autoimmune and inflammatory diseases, …

Based on a biological target, preclinical and clinical development requirements, Mabqi delivers readlily developable and functional human antibodies leads.

We support antibody discovery campaigns based on your targets of interest or maturation campaigns on parental hits or leads.

Our value proposition

Mabqi positions itself as a valuable partner in the early stages of therapeutic antibody discovery, enabling its partners to accelerate their drug development pipelines with promising and tailored antibody candidates:

Accelerate antibody discovery & development timelines
Maximize potential therapeutic lead candidates
Provide robust, reliable scientific results

By partnering with us, you’ll leverage cutting-edge capabilities that streamline your antibody discovery journey from initial concept to validated therapeutic potential.

How can Mabqi support your programs?

DISCOVERY – LiteMab© & LiteMab© Sense

Generating plug & play antibody functional hits or tumor-selective conditionally active immunotherapies

Our antibody discovery team offer comprehensive solutions to develop well-characterized conventional antibodies and pH-sensitive antibodies customized for your specific targets:

Platforms:
- LiteMab© based on our naive synthetic antibody library for conventional antibody discovery
- LiteMab© Sense based on pH-sensitive dedicated library to generate pH-dependent antibodies

Phage – yeast display selection process optimized for rapid identification of best conventional or pH-sensitive clones. AI can be used for additional optimization
Full characterization & functional validation
Confirmation of pH-sensitive functionality: in vitro binding and kinetics
Additional functional assays such as internalization assays for ADC development, in vitro cytotoxicity on target expressing cells, or other assays on-demand

AFFINITY MATURATION – LiteMab© Neo & LiteMab© NeoSense

Powering your pipeline with next-generation antibodies

Based on parental hits or leads, we can manage maturation programs on a lead candidate to boost parental antibodies’ affinity, specificity, and developability:

AI-powered design of a customized antibody library based on parental clone.
Thanks to our know-how in library design, diversity is introduced at selected and variable positions and destabilizing positions are avoided.
Dual display technology platform (Phage display -yeast display): selection process optimized for rapid identification of best clones
Additional AI tools can be used for further optimization
Comprehensive characterization and functional validation for selected antibodies.

Maturation campaigns can also enable to increase the therapeutic index of antibodies in development or on the market.

For Conditionally active antibodies, our expert team will design of a customized pH-sensitive antibody library thanks to our know-how in pH sensitive antibody design. Diversity is introduced at selected and variable positions to promote pH-sensitivity and avoid destabilizing positions.

Explore our expertise in affinity maturation and conditionally active pH-sensitive antibody discovery!

Streamlined discovery workflow

Our streamlined antibody discovery workflow integrates cutting‑edge synthetic libraries and AI‑powered screening technologies to rapidly deliver high‑quality, fully human therapeutic candidates. From target to validated lead, we combine robust selection, in‑depth characterization, and functional validation into a single, efficient process tailored for complex biologics development.

Optimized antibody discovery: Ready‑to‑use fully human synthetic suite of libraries (HuscI2™, pHuscI2™) combined with AI‑powered phage and yeast display for fast, high‑quality hit generation.
Versatile screening on diverse formats: Bio‑panning performed on proteins, peptides, cells, liposomes, VLPs, and other complex targets to identify relevant binders.
In‑depth hit characterization: Comprehensive profiling of binding affinity, EC50 potency, epitope specificity, cross‑reactivity, and cell‑based binding using flow cytometry.
Rigorous functional validation: Internalization assays, direct cytotoxicity assays, and fit‑for‑purpose functional testing to confirm therapeutic relevance and mechanism of action.

Learn about our antibody discovery and maturation workflow and capabilities.

Seeking an Integrated Solution for faster, leaner development-harnessing best-in-class expertise for complex biologics?

Mabqi and Abzena unite their expertise to provide a seamless end-to-end solution for antibody discovery and development :

Combined scientific know-how and technical support for clients
Cutting-edge scientific and technical capabilities for complex biologics
Science & results-driven partnership
Clear, easy-to-understand mode of operation of the partnership

Looking for a partner?

Together, let’s innovate to improve lives and advance human health!

For questions about accessing our LiteMab© Antibody Discovery Studio, leveraging our discovery and maturation programs, integrated solutions for discovery & devlopement of complex biologics or discussing strategic partnerships, please contact us.