Selected scientific publications from Mabqi teams and founders
Targeting RGMb interactions: Discovery and preclinical characterization of potent anti-RGMb antibodies blocking multiple ligand bindings.
Maria Meira, Aurore Frey, Neila Chekkat, Magda Rybczynska, Zaki Sellam, Joon Seok Park, Francesca Smylie Gazzaniga, Alexia Parmentier, Marianne Le Gall, Gordon James Freeman, Dennis Lee Kasper, Arlene Helen Sharpe, Eric Rambeaux, and Abdijapar Shamshiev
Trpv6 channel targeting using monoclonal antibody induces prostate cancer cell apoptosis and tumor regression.
Aurélien Haustrate, Clément Cordier, George Shapovalov, Adriana Mihalache, Emilie Desruelles, Benjamin Soret, Nadège Charlène Essonghé, Corentin Spriet, Maya Yassine, Alexandre Barras, Johanna Marines, Lindsay B Alcaraz, Sabine Szunerits, Gautier Robin, Pierre Gosset, Natalia Prevarskaya, V’yacheslav Lehen’kyi
Antibody-mediated neutralization of galectin-3 as a strategy for the treatment of systemic sclerosis.
Céline Ortega-Ferreira, Perrine Soret, Gautier Robin, Silvia Speca, Sandra Hubert, Marianne Le Gall, Emiko Desvaux, Manel Jendoubi, Julie Saint-Paul, Loubna Chadli , Agnès Chomel , Sylvie Berger , Emmanuel Nony , Béatrice Neau, Benjamin Fould , Anne Licznar, Franck Levasseur, Thomas Guerrier, Sahar Elouej, Sophie Courtade-Gaïani, Nicolas Provost, The Quyen Nguyen , Julien Verdier, David Launay, Frédéric De Ceuninck
Immunotherapy of triple-negative breast cancer with cathepsin D-targeting antibodies.
Yahya Ashraf, Hanane Mansouri, Valérie Laurent-Matha, Lindsay B Alcaraz, Pascal Roger, Séverine Guiu, Danielle Derocq, Gautier Robin, Henri-Alexandre Michaud, Helène Delpech, Marta Jarlier, Martine Pugnière, Bruno Robert, Anthony Puel, Lucie Martin, Flavie Landomiel, Thomas Bourquard, Oussama Achour, Ingrid Fruitier-Arnaudin, Alexandre Pichard, Emmanuel Deshayes, Andrei Turtoi, Anne Poupon, Joëlle Simony-Lafontaine, Florence Boissière-Michot, Nelly Pirot, Florence Bernex, William Jacot, Stanislas du Manoir, Charles Theillet, Jean-Pierre Pouget, Isabelle Navarro-Teulon, Nathalie Bonnefoy, André Pèlegrin, Thierry Chardès, Pierre Martineau, Emmanuelle Liaudet-Coopman.
Construction of Synthetic Antibody Libraries.
Déborah Caucheteur, Gautier Robin, Vincent Parez, Pierre Martineau
Construction of a Synthetic Antibody Gene Library for the Selection of Intrabodies and Antibodies.
Déborah Caucheteur, Gautier Robin, Vincent Parez, Pierre Martineau
Restricted diversity of antigen binding residues of antibodies revealed by computational alanine scanning of 227 antibody-antigen complexes.
Gautier Robin, Yoshiteru Sato, Dominique Desplancq, Natacha Rochel, Etienne Weiss, Pierre Martineau.
J. Mol. Biol, 2014
Generation of an intrabody-based reagent suitable for imaging endogenous proliferating cell nuclear antigen in living cancer cells.
Guillaume Freund, Dominique Desplancq, Audrey Stoessel, Robin Weinsanto, Annie-Paule Sibler, Gautier Robin, Pierre Martineau, Pascal Didier, Jérôme Wagner, Etienne Weiss.
By-Passing Large Screening Experiments Using Sequencing as a Tool to Identify scFv Fragments Targeting Atherosclerotic Lesions in a Novel In Vivo Phage Display Selection.
Kamel Deramchia, Marie-Josee Jacobin-Valat,Jeanny Laroche-Traineau, Stephane Bonetto, Stephane Sanchez, Pierre Dos Santos, Philippe Massot, Jean-Michel Franconi, Pierre Martineau , Gisele Clofent-Sanchez
Int. J. Mol. Sci. 2012
Synthetic customized scFv libraries.
Gautier Robin, Pierre Martineau.
Redirecting NK cells mediated tumor cell lysis by a new recombinant bifunctional protein.
Claire Germain, Emmanuelle Campigna, Imed Salhi, Sébastien Morisseau, Isabelle Navarro-Teulon, Jean-Pierre Mach, André Pèlegrin, Bruno Robert.
Protein Eng. Des. Sel. , 2008
A focused antibody library for selecting scFvs expressed at high levels in the cytoplasm.
Pascal Philibert, Audrey Stoessel, Wei Wang, Annie-Paule Sibler, Nicole Bec, Christian Larroque, Jeffery G Saven, Jérôme Courtête, Etienne Weiss , Pierre Martineau.
BMC Biotechnology, 2007
In vitro folding and thermodynamic stability of an antibody fragment selected in Vivo for high expression levels in Escherichia coli cytoplasm.
Pierre Martineau, Jean-Michel Betton.
J Mol Biol, 1999
Expression of an antibody fragment at high levels in the bacterial cytoplasm.
Pierre Martineau, Peter Jones, Greg Winter
J Mol Biol, 1998
Oral presentations and posters
Targeting tumor micro-environment with pH-sensitive human antibodies.
Anne Chevrel
12th Antibody Industrial Symposium, 2024
Development of pH-sensitive anti-HER2 antibodies to optimize therapeutic index.
Gautier Robin
Festival of Biologics Basel, 2023
Development of pH-sensitive anti-HER2 antibodies to optimize therapeutic index.
Gautier Robin, Thierry Mangeat.
10th Antibody Industrial Symposium, 2022
Rationally engineered human antibody libraries and their use for the selection of therapeutic antibodies.
Gautier Robin
Antibody Engineering & Therapeutics USA, 2021
Selected patents
Armand Bensussan, Bruno Robert, Pierre Martineau, Myriam Chentouf, Anne-Marie-Cardine, Jérôme Gustiniani. Monoclonal antibodies binding to the CD160 transmembrane isoform. Patent No WO 2018/077926A1
Bruno Robert, Christel Larbouret, Pierre Martineau, Marie-Alix Poul. Human monoclonal antibodies against AXL. Patent No WO 2016/091891A1
Alain Couvineau, Thierry Voisin, Pascal Nicole, Bruno Robert, Myriam Chentouf, Pierre Martineau. Human monoclonal antibodies against Orexin receptor-1. Patent No WO 2016/11351
Emmanuelle Liaudet-Coopman, Thierry Chardes, Pierre Martineau, Yahya Ashraf. Human monoclonal antibodies fragments inhibiting both the Cath-D catalytic activity and its binding to the lrp1 receptor Patent No WO 2016/188911