Therapeutic human antibodies Discovery campaigns & maturation programs

Supporting your antibody drug discovery and maturation programs

Maximize the success of your antibody discovery and maturation projects by leveraging our LiteMab© Antibody Discovery Studio.

Mabqi is committed to delivering 100% human functional antibody leads for various therapeutic applications and areas such as oncology, neuroscience, autoimmune and inflammatory diseases, …

Based on a biological target, preclinical and clinical development requirements, Mabqi delivers readlily developable and functional human antibodies leads.

We support antibody discovery campaigns based on your targets of interest or maturation campaigns on parental hits or leads.

Our value proposition

Mabqi positions itself as a valuable partner in the early stages of therapeutic antibody discovery, enabling its partners to accelerate their drug development pipelines with promising and tailored antibody candidates:

Accelerate antibody discovery & development timelines
Maximize potential therapeutic lead candidates
Provide robust, reliable scientific results

By partnering with us, you’ll leverage cutting-edge capabilities that streamline your antibody discovery journey from initial concept to validated therapeutic potential.

How can Mabqi support your programs?

Discovery campaigns

LiteMab & LiteMab Sense

Generating plug & play antibody functional hits or tumor-selective conditionally active immunotherapies

Our antibody discovery team offer comprehensive solutions to develop well-characterized conventional antibodies and pH-sensitive antibodies customized for your specific targets:

Platforms:
- LiteMab© based on our naive synthetic antibody library for conventional antibody discovery
- LiteMab Sense based on pHusci2™ designed library to generate conditionally active pH-dependent antibodies

Phage-yeast display selection process optimized for rapid identification of best conventional or pH-sensitive clones. AI can be used for additional optimization
Full characterization & functional validation
Confirmation of pH-sensitive functionality: in vitro binding and kinetics
Additional functional assays such as internalization assays for ADC development, in vitro cytotoxicity on target expressing cells, or other assays on-demand

Maturation programs

LiteMab Neo & LiteMab NeoSense

Powering your pipeline with next-generation antibodies

Based on parental hits or leads, we can manage maturation programs on a lead candidate to boost parental antibodies’ affinity, specificity, and developability:

AI-powered design of a customized antibody library thanks to our know-how in library design. Diversity is introduced at selected and variable positions and destabilizing positions are avoided.
Dual display technology platform (AI-powered Phage-yeast display): selection process optimized for rapid identification of best clones
Additional AI tools can be used for further optimization
Comprehensive characterization and functional validation for selected antibodies.

Maturation campaigns can also enable to increase the therapeutic index of antibodies in development or on the market.

For Conditionally active antibodies (CABs), our expert team will design of a customized pH-sensitive antibody library thanks to our know-how in pH sensitive antibody design. Diversity is introduced at selected and variable positions to promote pH-sensitivity and avoid destabilizing positions.

Explore our expertise in conditionally active pH-sensitive antibody discovery!

Looking for a partner?

Together, let’s innovate to improve lives and advance human health!

For questions about accessing our antibody display platform, leveraging our discovery and maturation programs, or discussing strategic partnerships, please contact us.